PAVE is a Marie Skłodowska-Curie Innovative Training Network. It is funded by the European Commission from 1st October, 2019 to 31th March, 2024.
A Nanovaccine Approach For The Treatment of Pancreatic Cancer By Multicomponent Immuno-Modulation: Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer deaths in men and women and still fatal in over 90% of patients. It is characterised by its extremely aggressive nature where it is also responsible for the highest mortality rate compared to other major cancers, resulting in excess of 250,000 deaths worldwide per annum. Current state-of-art therapies for advanced PDAC including chemo- and/or radiotherapy, despite extensive efforts, have met with only limited success.
Surgery is only applicable for those with early stages of the disease, or to relieve symptoms, if the cancer is blocking the bile duct or the bowel. There are two major reasons for the resistance of PDAC to conventional therapy. Firstly, PDAC has a very defining hallmark, where an abundance of stromal content is present in the tumour microenvironment (TME) to form a physical and biochemical barrier. Secondly, during progression of the disease, the body's immune system is hijacked to support the proliferation of the cancer. New approaches, such as immunotherapy, are therefore needed where it has already shown promise in overcoming many aspects of this resistance. Immunotherapy has the potential to treat minimal residual disease after pancreatic resection (surgery) as well as for metastatic and non-resectable PDAC. Our objective for this project is to bring together a multidisciplinary and intersectoral group to develop novel vaccine approaches, including use of multiple immunomodulating components.
The basic concept is to establish new strategies and approaches for cancer vaccinesas a primary objective, in conjunction with modulation of the tumour microenvironment (TME), in the treatment of pancreatic ductal adenocarcinoma (PDAC). In the PAVE project, we will use a new generation of nanoparticle (NP)-based vaccines for long-term immunity. In tandem, one of our study goals will be to also improve the availability of relevant experimental animal models that are replicative of the human immune system, where currently new cancer immuno- therapies need to be evaluated.
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